WHY WE NEED CRISPR TECHNOLOGY ?

CRISPR TECHNOLOGY 

CRISPR technology is undoubtedly one of the breakthrough discoveries in this era in genetic engineering. Originally discovered as an intrinsic component of prokaryotic defense against viruses, the CRISPR/Cas system has the prospect of becoming the leading technology in medical research, industrial biology, agriculture, and biofuel in the future.

Cas9 Protein | DNA Repair  

Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilodalton protein which plays a vital role in the immunological defense of certain bacteria against DNA viruses and plasmids, and is heavily utilized in genetic engineering applications. Its main function is to cut DNA and thereby alter a cell's genome. The CRISPR-Cas9 genome editing technique was a significant contributor to the Nobel Prize in Chemistry in 2020 being awarded to Emmanuelle Charpentier and Jennifer Doudna.[2]

Cas9是一個16萬道爾頓的蛋白質,它在某些細菌對DNA病毒和質粒的免疫反應中起到了重要作用。因為它的這一特性,它被大量應用於基因工程。2020年,兩位科學科學家,詹妮弗·杜德納和埃馬紐埃爾·沙爾龐捷因對CRISPR-Cas9的研究而獲得了當年的諾貝爾化學獎。 它又曾被稱為Cas5、Csn1或Csx12。

Based on the effector genes, the CRISPR/Cas system can be functionally classified into classes 1 and 2. Owing to its precise gene-editing capability, CRISPR has accelerated research related to drug design to treat diseases such as HIV and Cancer that have since long remained a challenge for conventional therapeutics.

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THE EFFECTOR GENES